For Patients and Caregivers

NOW APPROVED: Evrysdi tablet formulation1

For illustrative purposes only.

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Support for your patients, at your fingertips

Support for your patients, at your fingertips

MySMA support team from Genentech is available to answer questions and provide support service for your patients

MySMA SupportTM is a support service from Genentech that can help provide information about Evrysdi

The MySMA Support team is available to answer your patients’ questions and provide product education, including how to take Evrysdi. They can also help your patients understand their insurance coverage and refer them to appropriate financial assistance options to start and stay on Evrysdi.

The MySMA support team includes:

  • Dedicated support for healthcare providers
  • In-person and virtual support for patients
  • Case managers who partner closely with PALs and healthcare providers to help people living with SMA understand the health insurance process and identify potential financial support options for Genentech’s approved products; a Case Manager can also partner with the specialty pharmacy to help with a smooth delivery of Evrysdi
     

MySMA Support does not provide medical advice and is not a substitute for a patient’s medical team.

The completion and submission of coverage- or reimbursement- related documentation are the responsibility of the patient and healthcare provider. Genentech makes no representation or guarantee concerning coverage or reimbursement for any service or item.

*Enrollment in MySMA Support through the Evrysdi Start Form is mandatory to receive assistance through the program. Participation in MySMA Support is not necessary to receive treatment with Evrysdi.

Contact MySMA Support at (833) 387-9734 (Monday-Friday, 9 AM-8 PM ET)
or send a message through My Patient Solutions.
Contact MySMA Support at (833) 387-9734 (Monday-Friday, 9 AM-8 PM ET) or send a message through My Patient Solutions.
MySMA support resources for patients

Financial and insurance support resources for patients

Learn more

Important Safety Information and Indication

Indication

EVRYSDI is indicated for the treatment of spinal muscular atrophy (SMA) in pediatric and adult patients.

Interactions with Substrates of MATE Transporters

  • Based on in vitro data, Evrysdi may increase plasma concentrations of drugs eliminated via MATE1 or MATE2-K, such as metformin
  • Avoid coadministration of Evrysdi with MATE (multidrug and toxin extrusion) substrates. If coadministration cannot be avoided, monitor for drug-related toxicities and consider dosage reduction of the coadministered drug if needed

Pregnancy & Breastfeeding

  • Evrysdi may cause embryofetal harm when administered to a pregnant woman. In animal studies, administration of Evrysdi during pregnancy and/or lactation resulted in adverse effects on development. Advise pregnant women of the potential risk to the fetus
  • Pregnancy testing is recommended prior to initiating Evrysdi. Advise female patients to use contraception during treatment with Evrysdi and for at least 1 month after the last dose
  • There is a pregnancy exposure registry that monitors pregnancy and fetal/neonatal/infant outcomes in women exposed to Evrysdi during pregnancy. Physicians are encouraged to register patients and pregnant women are encouraged to register themselves by calling 1-833-760-1098 or visiting www.evrysdipregnancyregistry.com.
  • The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for Evrysdi and any potential adverse effects on the breastfed infant

Potential Effects on Male Fertility

  • Counsel male patients that fertility may be compromised by treatment with Evrysdi. Male patients may consider sperm preservation prior to treatment

Most Common Adverse Reactions

  • The most common adverse reactions in later-onset SMA (incidence in at least 10% of patients treated with Evrysdi and more frequent than control) were fever, diarrhea, and rash
  • The most common adverse reactions in infantile-onset SMA were similar to those observed in later-onset SMA patients. Additionally, adverse reactions with an incidence of at least 10% were upper respiratory tract infection (including nasopharyngitis, rhinitis), lower respiratory tract infection (including pneumonia, bronchitis), constipation, vomiting, and cough
  • The safety profile for presymptomatic patients is consistent with the safety profile for symptomatic SMA patients treated with Evrysdi in clinical trials

You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Genentech at 1-888-835-2555.

Please see full Prescribing Information for additional Important Safety Information.

 

 

    • Evrysdi® (risdiplam) Prescribing Information. Genentech, Inc.

      Evrysdi® (risdiplam) Prescribing Information. Genentech, Inc.

    • Data on file. Genentech USA, Inc.

      Data on file. Genentech USA, Inc.

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